Strategic decisions for safe and potential long-term therapy of osteoarthritis with NSAIDs

I.Yu. Golovach

Abstract


Pain is the most common symptom in general medical practice. Pain syndrome in osteoarthritis is characterized by a combination of pain mechanical, inflammatory, and also neuropathic origin, which gives it a persistent chronic course. Pain is also determined to be one of the risk factors and progression of osteoarthritis. The latest recommendations for osteoarthritis treatment recommend the use of non-steroidal anti-inflammatory drugs (NSAIDs) as an anesthetic and anti-inflammatory agents with long (constant or intermittent) cycles. Today, the issues of the analgesic potential of NSAIDs are inferior to their clinical safety. The problem of safety monitoring is a key aspect of the rational use of NSAIDs. The latest studies confirming gastrointestinal and cardiovascular safety of lornoxicam with long-term use are analyzed. Lornoxicam combines the optimal profile of analgesic potential and safety as regards long-term, permanent use, which makes it the drug of choice for the treatment of osteoarthritis. The favorable safety profile of lornoxicam is due to the fact that the drug is a balanced inhibitor of COX-1/COX-2 and has a relatively short half-life in comparison with other NSAIDs, which reduces the risk of its accumulation.

Keywords


osteoarthritis; pain; nonsteroidal anti-inflammatory drugs; lornoxicam; safety; long-term use

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DOI: https://doi.org/10.22141/1608-1706.4.18.2017.109341

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