Role of interleukin-6 in the diagnosis of infectious complications in patients with polytrauma

S.O. Gurev, O.S. Soloviov, O.M. Tanasienko


The problem of the day-to-day diagnosis of infectious diseases in affected people is limited to the effective monitoring of disease course, and it is topical at the present time. In the clinical practice, there are two basic problems in the diagnosis of severe infectious diseases. Inflammation that occurs after tissue damage in trauma is accompanied by a production of cytokines and acute phase proteins, determination of which may indicate the presence of inflammation and degree of its severity. In this regard, there is clear interest of researchers and clinicians to interleukin-6 (IL-6), which many authors consider as a specific marker of infection. On the example of 116 victims with polytrauma and various clinical forms of infectious complications, the role of IL-6 in the early diagnosis of inflammation was considered. A direct correlation was found between the level of IL-6 and the severity of infectious complication, as well as the possibility to diagnose it without existing clinical picture. The level of IL-6 allows to differentiate the development of local and generalized infection, to predict treatment and prognosis in victims with polytrauma.


victims; polytrauma; interleukin 6; inflammation; traumatic disease


Абу Салех Аммар Ибрахим. Роль цитокинов в патогенезе острого периода черепно-мозговой травмы: Автореф. дис… на соискание уч. степени канд. мед. наук: спец. 14.00.13 «Нервные болезни» / Абу Салех Аммар Ибрахим. — М., 2007. — 22 с.

Иммунологические маркеры воспаления и сепсиса при сочетанной механической травме / С.Ф. Багненко, Л.П. Пивоварова, М.Е. Малышев [и др.] // Инфекции в хирургии. — 2012. — № 1. — С. 22-27.

Кетлинский С.А. Цитокины / С.А. Кетлинский, А.С. Симбирцев. — СПб.: Фолиант, 2008. — 549 с.

Donelly T.G. Cytokine, complement and endotoxine profiles associated with the development of the adult respiratory syndrome after severe injury / T.G. Donelly, P. Meade, M. Jag-les // Crit. Care Med. — 2004. — Vol. 22. — P. 768-776.

Immunomodulation in polytrauma and polymicrobial sepsis — where do we stand? / C. Neunaber, C. Zeckey, H. Andruszkow et al. // Recent Pat Inflamm Allergy Drug Discov. — 2011. — Vol. 5, № 1. — P.17-25.

Menges P. Surgical trauma and postoperative immune dysfunction / P. Menges, W. Kessler, C. Kloecker // Eur. Surg. Res. — 2012. — 48(4). — 180-6.

Mira J.-P. Sepsis. Mechanismes immunitaires / J.-P. Mira, B. Vallet. — Paris, 2004. — P. 334.

Copyright (c) 2017 TRAUMA

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта