DOI: https://doi.org/10.22141/1608-1706.1.19.2018.126667

Metal included in the prosthetic knee joints in the hair of patients with gonarthrosis

N.V. Sokrut, F.V. Klymovytsky, O.V. Syniachenko

Abstract


Background. Gonarthrosis is one of the most common rheumatologic and orthopedic diseases, which cause a significant health and social damage, either to the ill people or to the society as a whole. Gonarthrosis is accompanied by microelementosis, with a violation in the body levels of many essential and toxic metals. After knee joint replacement, there is a change in the content of such me-tals as Co, Cr, Ti, and others, which are able to determine the survival of prosthesis and the further course of gonarthrosis. The purpose and objectives of the research — to determine the hair level of metals included in the composition of prosthetic knee joints (Al, Co, Cr, Fe, Mo, Ni, Ti, V) of patients with gonarthrosis, as well as to compare the values with concentrations of these trace elements in the blood, to evaluate the clinical and pathogenetic significance of this microelementosis with different variants of disease course. Materials and methods. We have examined 87 patients with gonarthrosis (45 % of them were men and 55 % — women, with an average age of 53 years). I, II and III stages of the disease were identified in 28, 41 and 31 % of observations, respectively, polyarthrosis — in 53 % of, osteochondrosis — is 92 %, spondylarthrosis of facet articulations — in 71 %, clinically overt synovitis (gonitis) — in 67 %. To study the level of metals in the body, we used atomic absorption spectrometer SolAAr-Mk2-MOZe with electrographitic atomizer (UK). Results. Microelementhosis in the blood of patients with gonarthrosis was observed in 41 % of cases, while in the hair — in 23 %, which is accompanied by increased levels of Ti and V in the blood serum on the background of reduced concentration of Fe that is accordingly observed in 40, 44 and 43 % of patients, and hair changes of metals are related to the increasing content of Al, Fe and Ti with decreasing parameters of Co, Cr and Mo in 46, 100, 22, 12, 29 and 45 % of cases. It depends on the radiographic stage of the disease, the presence of synovitis, the prevalence and severity of articular syndrome, is involved in the pathogenesis of lesions of the meniscus, bursitis, trabecular oedema of the patella, forming osteophytes, osteocytes and intraarticular Stieda bodies, which is correlated with osteoporosis (Al, Co, Cr, Ni), values of Cr, Ti and V in different objects of study (blood, hair) are correlated to each other, as well as have prognostic significance. Conclusions. Gonarthrosis occurs with changing blood and hair levels of metals contained in the total knee joints (Al, Co, Cr, Fe, Mo, Ti, V), which depends on the clinical course of the disease, determines the pathogenetic compositions of articular degenerative inflammatory lesions and forces the necessity to study microelementosis in the body of patients during dynamic observation after joint replacement.


Keywords


gonarthrosis; metals; hair; course; pathogenesis

References


Colotti G., Ilari A., Boffi A., Morea V. Metals and metal derivatives in medicine // Mini Rev. Med. Chem. — 2013. — № 13(2). — Р. 211-21.

Czekaj J., Ehlinger M., Rahme M., Bonnomet F. Metallosis and cobalt-chrome intoxication after hip resurfacing arthroplasty // J. Orthop. Sci. — 2016. — № 21(3). — Р. 389-94. — doi: 10.1016/j.jos.2015.06.001.

Hill J.C., Diamond O.J., O’Brien S., Boldt J.G., Stevenson M., Beverland D.E. Early surveillance of ceramic-on-metal total hip arthroplasty // Bone Joint J. — 2015. — № 97(3). — Р. 300-5. — doi: 10.1302/0301-620X.97B3.33242.

Kazi H.A., Perera J.R., Gillott E., Carroll F.A., Briggs T.W. A prospective study of a ceramic-on-metal bearing in total hip arthroplasty. Clinical results, metal ion levels and chromosome analysis at two years // Bone Joint J. — 2013. — № 95(8). — Р. 1040-4. — doi: 10.1302/0301-620X.95B8.31574.

Kiran M., Boscainos P.J. Adverse reactions to metal debris in metal-on-polyethylene total hip arthroplasty using a titanium-molybdenum-zirconium-iron alloy stem // J. Arthroplasty. — 2015. — № 30(2). — Р. 277-81. — doi: 10.1016/j.arth.2014.06.030.

Kubaszewski L., Zioła-Frankowska A., Frankowski M., Rogala P., Gasik Z., Kaczmarczyk J. et al. Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques // J. Orthop. Surg. Res. — 2014. — № 25(9). — Р. 99-109. — doi: 10.1186/s13018-014-0099-y.

Lamberg E.M., Streb R., Werner M., Kremenic I., Penna J. The 2- and 8-week effects of decompressive brace use in people with medial compartment knee osteoarthritis // Prosthet. Orthot. Int. — 2016. — № 40(4). — Р. 447-53. — doi: 10.1177/0309364615589537.

Leung Y.Y., Ma S., Noviani M., Wong S.B., Lee C.M., Soh I.A. et al. Validation of screening questionnaires for evaluation of knee osteoarthritis prevalence in the general population of Singapore // Int. J. Rheum. Dis. — 2017. — № 21(12). — Р. 132-8. — doi: 10.1111/1756-185X.13252.

Lützner J., Hartmann A., Dinnebier G., Spornraft-Ragaller P., Hamann C., Kirschner S. Metal hypersensitivity and metal ion levels in patients with coated or uncoated total knee arthroplasty: a randomised controlled study // Int. Orthop. — 2013. — № 37(10). — Р. 1925-31. — doi: 10.1007/s00264-013-2010-6.

Malek I.A., Rogers J., King A.C., Clutton J., Winson D., John A. The interchangeability of plasma and whole blood metal ion measurement in the monitoring of metal on metal hips // Arthritis. — 2015. — № 2015. — Р. 216785. — doi: 10.1155/2015/216785.

Malzahn J. Conservative and operative treatment of working age patients with gonarthritis. Economic conside-

rations // Orthopade. — 2014. — № 43(6). — Р. 503-6, 508-10. — doi: 10.1007/s00132-014-2295-1.

Matharu G.S., Berryman F., Brash L., Pynsent P.B., Treacy R.B., Dunlop D.J. Predicting high blood metal ion concentrations following hip resurfacing // Hip. Int. — 2015. — № 25(6). — Р. 510-9. — doi: 10.5301/hipint.5000258.

McQueen P., Gates L., Marshall M., Doherty M., Arden N., Bowen C. The effect of variation in interpretation of the La Trobe radiographic foot atlas on the prevalence of foot osteoarthritis in older women: the Chingford general population cohort // J. Foot Ankle Res. — 2017. — № 8(10). — Р. 54-9. — doi: 10.1186/s13047-017-0239-9.

Nelson A.E. Osteoarthritis year in review 2017: clinical // Osteoarthritis Cartilage. — 2017. — № 8(12). — Р. 348-51. — doi: 10.1016/j.joca.2017.11.014.

Plotnikoff R., Karunamuni N., Lytvyak E., Penfold C., Schopflocher D., Imayama I. et al. Osteoarthritis prevalence and modifiable factors: a population study // BMC Public Health. — 2015. — № 30(15). — Р. 1195. — doi: 10.1186/s12889-015-2529-0.

Steinberg J., Shah K.M., Gartland A., Zeggini E., Wilkinson J.M. Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study // J. Orthop. Res. — 2017. — № 18(1). —

Р. 133-9. — doi: 10.1002/jor.23525.

Stejskal V., Reynolds T., Bjørklund G. Increased frequency of delayed type hypersensitivity to metals in patients with connective tissue disease // J. Trace Elem. Med. Biol. — 2015. — № 31. — Р. 230-6. — doi: 10.1016/j.jtemb.2015.01.001.

Vina E.R., Kwoh C.K. Epidemiology of osteoarthritis: lite-rature update // Curr. Opin. Rheumatol. — 2017. — № 8(12). — Р. 142-9. — doi: 10.1097/BOR.0000000000000479.

Weber P., Steinbrück A., Paulus A.C., Woiczinski M., Schmidutz F., Fottner A. et al. Partial exchange in total hip arthroplasty: what can we combine? // Orthopade. — 2017. — № 46(2). — Р. 142-7. — doi: 10.1007/s00132-016-3380-4.




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