Metal included in the prosthetic knee joints in the hair of patients with gonarthrosis

N.V. Sokrut, F.V. Klymovytsky, O.V. Syniachenko


Background. Gonarthrosis is one of the most common rheumatologic and orthopedic diseases, which cause a significant health and social damage, either to the ill people or to the society as a whole. Gonarthrosis is accompanied by microelementosis, with a violation in the body levels of many essential and toxic metals. After knee joint replacement, there is a change in the content of such me-tals as Co, Cr, Ti, and others, which are able to determine the survival of prosthesis and the further course of gonarthrosis. The purpose and objectives of the research — to determine the hair level of metals included in the composition of prosthetic knee joints (Al, Co, Cr, Fe, Mo, Ni, Ti, V) of patients with gonarthrosis, as well as to compare the values with concentrations of these trace elements in the blood, to evaluate the clinical and pathogenetic significance of this microelementosis with different variants of disease course. Materials and methods. We have examined 87 patients with gonarthrosis (45 % of them were men and 55 % — women, with an average age of 53 years). I, II and III stages of the disease were identified in 28, 41 and 31 % of observations, respectively, polyarthrosis — in 53 % of, osteochondrosis — is 92 %, spondylarthrosis of facet articulations — in 71 %, clinically overt synovitis (gonitis) — in 67 %. To study the level of metals in the body, we used atomic absorption spectrometer SolAAr-Mk2-MOZe with electrographitic atomizer (UK). Results. Microelementhosis in the blood of patients with gonarthrosis was observed in 41 % of cases, while in the hair — in 23 %, which is accompanied by increased levels of Ti and V in the blood serum on the background of reduced concentration of Fe that is accordingly observed in 40, 44 and 43 % of patients, and hair changes of metals are related to the increasing content of Al, Fe and Ti with decreasing parameters of Co, Cr and Mo in 46, 100, 22, 12, 29 and 45 % of cases. It depends on the radiographic stage of the disease, the presence of synovitis, the prevalence and severity of articular syndrome, is involved in the pathogenesis of lesions of the meniscus, bursitis, trabecular oedema of the patella, forming osteophytes, osteocytes and intraarticular Stieda bodies, which is correlated with osteoporosis (Al, Co, Cr, Ni), values of Cr, Ti and V in different objects of study (blood, hair) are correlated to each other, as well as have prognostic significance. Conclusions. Gonarthrosis occurs with changing blood and hair levels of metals contained in the total knee joints (Al, Co, Cr, Fe, Mo, Ti, V), which depends on the clinical course of the disease, determines the pathogenetic compositions of articular degenerative inflammatory lesions and forces the necessity to study microelementosis in the body of patients during dynamic observation after joint replacement.


gonarthrosis; metals; hair; course; pathogenesis


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