Effectiveness of Nimedar application in orthopedic practice

I.M. Zazirnyi


The aim of the study was to evaluate the efficacy and safety of using Nimedar in comparison with nimesil in the treatment of patients with early stages of knee osteoarthritis, low back pain and in the early postoperative period after endoscopic knee surgery. This clinical study was prospective. There were formed 3 clinical groups of patients. A total of 70 patients were enrolled in the study: 30 of them were included in the control group, 30 — in the study group, 10 — in the retrospective group. Patients in the control group received nimesil, persons in the experimental group — Nimedar, patients in the retrospective group did not receive any medicine. The results of the prospective clinical study demonstrated the efficacy of Nimedar application manufactured by PrJSC “Pharmaceutical Firm “Darnitsa” in the treatment of patients with the first stage of knee osteoarthritis and low back pain without any neurological signs and in the postoperative period after arthroscopic partial meniscectomy.


anesthesia; Nimedar; nimesil; osteoarthritis of the knee joint; osteochondrosis of the lumbar spine; arthroscopic meniscus resection


Bennet A., Villa G. Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities // Exp. Opin. Pharmacother. — 2000. — 1. — 277-286.

Bernareggi A. Clinical pharmacokinetics of nimesulide // Clin. Pharmacokinet. — 1998. — 35(4). — 247-274.

Bevilacqua M., Devogelaer J.P., Righini V., Famaey J.P., Manicourt D.H. Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study // Int. J. Clin. Pract. Suppl. — 2004. — 144. — 13-19.

Bianchi M., Ferrario P., Balzarini P., Broggini M. Plasma and synovial fluid concentrations of nimesulide and its main metabolite after a single or repeated oral administration in patients with knee osteoarthritis // J. Int. Med. Res. — 2006. — 34. — 348-354.

Bloodsworth A., O’Donnell V.B., Freeman B.A. Nitric oxide regulation of free radical and enzyme mediated lipid and lipoprotein oxidation // Aterioscler. Thromb. Vasc. Biol. — 2000. — 20(7). — 1707-1715.

Casolaro V., Meliota S., Marino O. et al. Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells // J. Pharmacol. Exp. Ther. — 1993. — 267(3). — 1375-85.

Conforti A., Leone R., Moretti U., Mozzo F., Velo G. Adverse drug reactions related to the use of NSAIDs with a focus on nimesulide: results of spontaneous reporting from a Northern Italian area // Drug Saf. — 2001. — 24(14). — 1081-1090.

Famaey J.P. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview // Inflamm. Res. — 1997. — 46. — 437-46.

Grossman C.J., Wiseman J., Lucas F.S. et al. Inhibition of constitutive and inducible cyclo-oxygenase activity in human platelets and mononuclear cells by NSAIDs and COX 2 inhibitors // Inflam. Res. — 1995. — 44. — 253-7.

Henrotin Y.E., Labasse A.H., Simonis P.E. et al. Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro // Clin. Exp. Rheumatol. — 1999. — 17. — 151-160.

Kullich W.C., Niksic F., Klein G. Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study // Int. J. Clin. Pract. Suppl. — 2002. — 128. — 24-29.

Laporte J.R., Ibanez L., Vidal X. et al. Upper gastrointestinal bleedings, associated with the use of NSAIDs: newer versus older agents // Drug. Saf. — 2004. — 27(6). — 411-420.

Pelletier J.P., Di Battista J.A., Zhang M. et al. Effect of nimesulide on glucocorticoid receptor activity in human synovial fibroblasts // Rheumatology. — 1999. — 38 (Suppl. 1). — 11-13.

Pelletier J.P., Mineau F., Fernandes J.C. et al. Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts // Clin. Exp. Rheumatol. — 1997. — 15. — 393-398.

Rainsford K. and Members of the Consensus Report Group on Nimesulide. Nimesulide — a multifactorial approach to inflammation and pain: scientific and clinical consensus // Current Medical Research and Opinion. — 2006. — 22(2). — 1161-1170.

Rainsford K.D. Nimesulide: overview of properties and applications // Drugs of Today. — 2001. — 37 (Suppl. B). — 3-7.

Rainsford K.D. Relationship of nimesulide safety to its pharmacokinetics: assessment of adverse reactions // Rheumatol. (Oxford). — 1999. — 38 (Suppl. 1). — 4-10.

Rossoni G., Berti F., Buschi A. et al. New data concer-ning the antianaphylactic and antihistaminic activity of nimesulide // Drugs. — 1993. — 46 (Suppl. 1). — 22-28.

Scher J.U., Pillinger M.H., Abramson S.B. Nitric

oxide synthases and osteoarthritis // Curr. Rheumatol. Rep. — 2007. — 9(1). — 9-15.

Кузьменко В.В., Фокин В.А., Маттис Э.Р., Соков Е.Л., Бармотин Г.В., Назарова Т.Б. Психологические методы количественной оценки боли // Советская медицина. — 1986. — 10. — С. 44-48.

Atlas S.J. The Quebec Task Force classification for Spinal Disorders and severity,treatment and outcomes of shiatica and lumbar spinal stenosis / S.J. Atlas, R.A. Deyo, D.L. Patrick et al. // Spine. — 1996. — Vol. 21. — P. 2885-2892.

Copyright (c) 2018 TRAUMA

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта