DOI: https://doi.org/10.22141/1608-1706.4.19.2018.142108

Effect of negative pressure therapy on inflammation and regeneration in extremity gunshot wounds in early period

L.Yu. Naumenko, O.M. Horehliad

Abstract


Although vacuum-assisted closure approved as cost-effective and a powerful therapeutic method over the past two decades, the variety of injuries due to gunshot (including battle injuries) wounds requires further investigation of negative pressure therapy effect on wound healing. The aim of the work was a comprehensive analysis of effectiveness of vacuum-assisted closure (VAC) by the changes in leucogram and cytogram from wound content in patients with severe gunshot wounds. VAC was found to improve regeneration process confirmed by faster change of degenerative-necrotic cytogram from wound content, to accelerate normalization of leucogram parameters due to reduction of necrobiosis, increase vascular endothelial growth factor in blood serum, diminish the portion of purulent-septic complications, decrease the period for reconstructive interventions start in patients undergone negative pressure therapy by an average of 5.2 ± 0.8 day.


Keywords


wound healing; negative pressure therapy; leucogram; cytogram; surface biopsy; VEGF

References


Taylor C., Jaffery S. Management of military wounds in modernera // Wounds. — 2009. — 5. — Р. 50-58.

Morykwas M.J., Simpson J., Punger K., Argenta A., Kremers L., Argenta J. Vacuum-assisted closure: state of basic research and physiologic foundation // Plast. Reconstr. Surg. — 2006. — 117. — Р. 121-126.

Geiger S., McCormick F., Chou R., Wangel A.G. Warwounds: lessons learned from Operation Iraqi Freedom // Plast. Reconstr. Surg. — 2008. — 122. — Р. 146-153.

Horrocks C. Blast injuries: biophysics, pathophysiology and management principles // J. R. Army Med. Corps. — 2001. — 147. — Р. 28-40.

Murray C.K., Hsu J.R., Solomkin J.S. et al. Prevention and management of infections associated with combat-related extremities injuries // J. Trauma. — 2008. — 64. — Р. 238-251.

Naumenko L.Y., Horehliad O.M., Mamet’ev A.A., Kostrica K.Y., Roleof V.A. Cin treatment of open severe polystructural damage of extremities // Trauma. — 2016. — 17(3). — Р. 25-26.

Naumenko L., Horehliad O., Mametyev A., Kostrytcya K., Domansky A. Healing of severe polystructural limb wounds using vacuum therapy // Orthopaedics, Traumatology and Prosthetics. — 2017. — 4. — doi: 10.15674/0030-59872017457-61.

Островский В.К., Свитич Ю.М., Вебер В.Р. Лейкоцитарный индекс интоксикации при острах гнойных и воспалительных заболеваниях легких // Вестн. хирургии. — 1983. — Т. 131, № 11. — С. 21-24.

Камаев М.Ф. Инфицированная рана и ее лечение. — М.: Медицина, 1970. — 159 с.

Морфологічні особливості репаративних процесів у ранах бойового характеру під впливом вакуум-асистованої терапії / О.Є. Лоскутов, О.М. Горегляд, О.О. Бондаренко, Н.С. Бондаренко // Morphologia. — 2018. — Т. 12, № 1. — С. 20-28.

Горегляд А.М. Изменение контаминированности ран под. действием локального применения негативного давления // Вестник Витебского государственного медицинского университета. — 2018. — Т. 17, № 2. — С. 63-69.

Scherer S.S., Pietramaggiori G., Mathews J.C., Prsa M.J., Huang S., Orgill D.P. The mechanism of action of vacuum-assisted closure device. Plast. Reconst. Surg. — 2008. — 122. — Р. 786-799.

Orgill D.P., Manders E.K., Sumpio B.E. et al. The mechanism of action of vacuum-assisted closure: moretolearn // Surgery. — 2009. — 146. — Р. 40-51

Huang C., Leavitt T., Bayer L.R., Orgill D.P. Effect of negative pressure wound therapy on wound healing // Curr. Probl. Surg. — 2014. — 51. — Р. 301-331.

McNulty A.K., Schmidt M., Feeley T., Kieswetter K. Effects of negative pressure wound therapy on fibroblast viability, chemotactic signaling, and proliferation in a provisional wound (fibrin) matrix // Wound Repair Regen. — 2007. — 15. — Р. 838-846.

Erba P., Ogawa R., Ackermann M. et al. Angiogenesis in wounds treated by microdeformational wound therapy // Ann. Surg. — 2011. — 253. — Р. 402-409.

Borgquist O., Ingemansson R., Malmsjo M. Individualizing the negative pressure wound therapy for optimal wound healing: a focused review of literature // Ostomy Wound Mana­ge. — 2011. — 57. — Р. 44-54.




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