DOI: https://doi.org/10.22141/1608-1706.5.19.2018.146645

Endothelial function of the vessels and rheological blood properties in burn injury

G.Ye. Samoilenko, A.I. Kolesnik, O.V. Syniachenko, O.V. Andreiev

Abstract


Background. The severity of burn injury reflects the degree of vascular damages with paravasal changes, the development of the disturbances of vascular endotheliocyte function and the erythrocyte­platelet unit of rheological blood properties. The purpose of the research is to study the clinical and pathogenetic significance of vascular endothelial dysfunction and disturbances of the rheological properties of blood serum in case of burn injury. Materials and methods. Under survey, there were 117 patients with burns, 83 % of men and 17 % of women aged 14 to 79 years (44 years on the average). The examination period after burn injury was up to 7 days (2 days on the average). The indices of vascular endothelial function were studied by the immunoenzyme method and the rheology of blood — by the physicochemical method of axisymmetric drop shape. Results. In patients with burn injury, the indices of vascular endothelial growth factor (VEGF) were 465.0 ± 10.9 pg/ml, endothelin­1 (ET1) — 5.0 ± 0.2 pg/ml, thrombo­xane A2 (TxA2) — 12.0 ± 0.9 ng/ml, prostacyclin (PgI2) — 44.0 ± ± 4.2 ng/ml, surface viscosity (SV) — 14.00 ± 0.23 mN/m, elasticity — 43.0 ± 0.6 mN/m, viscoelastic modulus — 24.0 ± 0.8 mN/m, surfactant index — 48.0 ± 0.8 r.u. In comparison with the control group of apparently healthy people, burns are associated with an increase of VEGF level by 5.2 times, ET1 — by 28 %, TxA2 — by 69 % with the decrease of PgI2 level by 35 % and SV by 12 % that is observed in 98, 54, 27, 32 and 42 % of cases, respectively, and the indices correlate with each other (SV ET1, SV PgI2) and with laboratory criteria of the disease, they depend on the severity of the pathological process (the degree of respiratory burn, integral seve­rity of injury and shock), affect the survival of the injured persons, and the level of VEGF has prognostic significance. Conclusions. Violations of the endothelial function of blood vessels and the rheological properties of blood serum are involved in pathogenetic constructions of burn injury.


Keywords


burn injury; pathogenesis; endothelial function of blood vessels; blood rheology

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