Osteoporosis in stroke patients

V.V. Povoroznyuk, M.A. Bystrytska, N.M. Koshel


Background. Stroke and osteoporosis are age-dependent pathologies that affect elderly people mostly. The purpose of the study was to evaluate the features of bone mineral density (BMD) in stroke patients. Materials and methods. We examined 84 stroke patients and 124 persons of the corresponding age and sex without neurological pathology, who made up the comparison group. The activities of daily living were determined by the Barthel index. Results. The frequency of osteoporosis was significantly higher in stroke patients than in the comparison group (16.7 versus 4.0 %). BMD in stroke women was significantly lower at all levels, in men differences are recorded at the level of radius 33% and total body. With an increase in the length of the post-stroke period, men had a decrease in BMD at the level of the femoral neck (F = 3.12; p = 0.038) and radius 33% (F = 3.26; p = 0.034), in women — at the level of all surveyed sites. Correlations were recorded between the Barthel index and BMD at the level of the lumbar spine (r = 0.37, p < 0.05), femoral neck and proximal femur (r = 0.30, p < 0.05 and r = 0.26, p < 0.05), at the level of the upper and lower extremities (r = 0.27, p < 0.05, r = 0.32, p < 0.05), as well as at the total body and radius 33% (r = 0.33, p < 0.05, r = 0.38, p < 0.05). A model has been created for predicting the development of osteoporosis in stroke patients, taking into account the parameters of body mass, the duration of the post-stroke period and the total Barthel index. Conclusions. The results of our study show that stroke is a risk factor for the development of osteoporosis. The degree of bone loss depends on the functional deficit, the duration of the post-stroke period, and has gender features.


osteoporosis; bone mineral density; Barthel index; stroke


Carda S, Cisari C,·Invernizzi M, Bevilacqua M. Osteoporosis after Stroke: A Review of the Causes and Potential Treatments. Cerebrovasc Dis 2009;28:191–200

Mishchenko T. S. Epidemiology of cerebrovascular diseases and organization of medical care for patients with stroke in Ukraine. Ukrains'kyi Visnyk Psykhonevrolohii. 2017; 25(1): 22-24. [In Ukranian]

Schnitzer TJ, Harvey RL, Nack SH, Supanwanid P, Maskala-Streff L, Roth E. Bone mineral density in patients with stroke: relationship with motor impairment and functional mobility. Top Stroke Rehabil. 2012 Sep-Oct;19(5):436-43. doi: 10.1310/tsr1905-436.

Jorgensen L, Engstad T, Jacobsen BK. Bone mineral density in acute stroke patients: low bone mineral density may predict first stroke in women. Stroke. 2001;32:47-51.

Cawthon PM. Gender Differences in Osteoporosis and Fractures. Clin Orthop Relat Res 2011; 469: 1900-1905.

Kapral MK., Fang J, Alibhai SM, Cram P, Cheung AM., Casaubon LK., Prager M., Stamplecoski M., Rashkovan B., Austin P.C. Risk of fractures after stroke: Results from the Ontario stroke registry. Neurology. 2017;88:57–64. doi: 10.1212/WNL.0000000000003457.]

Girijala RL, Sohrabji F, Bush RL. Sex differences in stroke: Review of current knowledge and evidence. Vasc Med 2017; 22:135-145.

Ahnstedt H, McCullough LD, Cipolla MJ. The Importance of Considering Sex Differences in Translational Stroke Research. Transl Stroke Res 2016; 7: 261-273.

Boling EP. Gender and osteoporosis: similarities and sex-specific differences. J Gend Specif Med 2001; 4:36-43.

Lee S, Cho A, Butcher K, Kim T, Ryu S, Kim Y. Low bone mineral density is associated with poor clinical outcome in acute ischemic stroke. Int J Stroke 2011; Dec 8:188-191.

Huo K, Hashim SI, Yong KL, Su H, Qu QM. Impact and risk factors of post-stroke bone fracture. World J Exp Med. 2016;6(1):1-8.

Sato Y, Maruoka H, Honda Y, Asoh T, Fujimatsu Y, Oizumi K. Development of osteopenia in the hemiplegic finger in patients with stroke. Eur Neurol. 1996; 36: 278-283.

Sato Y, Kuno H, Asoh T, Honda Y, Oizumi K. Effect of immobilization on vitamin D status and bone mass in chronically hospitalized disabled stroke patients. Age Ageing. 1999; 28: 265-269.

Jorgensen L, Crabtree NJ, Reeve J, Jacobsen BK. Ambulatory level and asymmetrical weight bearing after stroke affects bone loss in the upper and lower part of the femoral neck differently: bone adaptation after decreased mechanical loading. Bone. 2000 Nov;27(5):701-7.

NIH Stroke Scale Accessed June 30, 2018.

Official Positions 2015 ISCD (Adult & Pediatric). Accessed June 30, 2018.

Kim, HD, Kim SH, Kim DK, Jeong HJ, Sim YJ, Kim GC. Change of Bone Mineral Density and Relationship to Clinical Parameters in Male Stroke Patients. Annals of Rehabilitation Medicine, 2016; 40(6), 981–988.

Beaupre GS, Lew HL. Bone-density changes after stroke. Am J Phys Med Rehabil 2006; 85:464-472.

Lazoura O, Groumas N, Antoniadou E et al. Bone mineral density alterations in upper and lower extremities 12 months after stroke measured by peripheral quantitative computed tomography and DXA. J Clin Densitom 2008; 11:511-517.

Bagger YZ, Tankó LB, Alexandersen P, Qin G, Christiansen C. Radiographic measure of aorta calcification is a sitespecific predictor of bone loss and fracture risk at the hip J Intern Med. 2006 Jun;259(6):598-605.

Bagger Y.Z., Rasmussen H. B., Alexandersen P. et al. Link between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis perse? Osteoporos Int. 2007 Apr;18(4):505-12.

Nishkumay О. І. Calcification of blood vessels, atherosclerosis and osteoporosis: is there a relationship?. UMJ Heart & Vessels. 2016; 1: 107-112. [In Ukranian]

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