Silicon content in blood and synovial fluid of patients with rheumatoid arthritis: clinical-pathogenetic significance of microelementosis
Keywords:rheumatoid arthritis, course, pathogenesis, silicon, blood, synovial fluid
Background. The prevalence of rheumatoid arthritis (RA) among the world’s population is about 1 %, and among certain populations of people it reaches 5–7 %. The risk factors for the development and high rates of RA progression include high concentrations of quartz (silicon (Si) dioxide) in the inhaled air, the toxic effect of which is considered as one of the most powerful pathogenetic factors of this disease. The purpose of the work was to evaluate the clinical and pathogenetic significance of silicon microelementosis in RA. Materials and methods. Eighty-three patients with RA were examined (22 % were males and 78 % — females aged from 22 to 75 (mean of 45) years). The duration of the disease from the first signs of its manifestation was 9 years. Systemic form of the disease was diagnosed in 19 % of cases, RA seropositive for rheumatoid factor was detected in 68 %, for cyclic citrullinated peptide antibodies — in 80 % of individuals. The content of Si in the blood serum and in 19 patients — in cerebrospinal fluid was determined using an atomic absorption spectrometer SolAAr-Mk2-MOZe with an electrographite atomizer (Great Britain). Using a computer tensiometer PAT2-Sinterface (Germany), the parameters of the surface tension of blood serum and synovial fluid were investigated with a surface life time of 0.01 sec and tending to infinity, and their ratio was calculated. Results. RA is accompanied by the absence of probable changes in the level of silicon. Si microelementosis is associated with the clinical, radiographic and sonographic signs of the disease course, the degree of activity and severity of arthritis, and silicon imbalance is involved in the pathogenesis of the articular syndrome, damage to the skeletal muscle, the peripheral nervous system, wherein, Si indicators in blood may have prognostic significance.
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