Efficacy and Safety of Treating Patients with Knee Osteoarthritis Treatment Using Hydrolyzed Collagen (FORTIGEL®)

V.Ye. Kondratiuk, S.Kh. Ter-Vartanian

Abstract


Objective of the study — to assess the efficacy and safety of using рroFLEX (Schonen, Switzerland) — hydrolyzed collagen (FORTIGEL®) in patients with knee osteoarthritis. An open clinical study included 30 patients (8 men and 22 women) aged 45–74 years (mean age 59 ± 8 years) with knee osteoarthritis, the disease duration averaged 8.9 ± 6.0 years. All patients in addition to nonsteroidal anti-inflammatory drug received hydrolyzed collagen (FORTIGEL®)orally at a dose of 10 g per day. Duration of treatment — 3 months.
There was a positive dynamics during treatment period, which was proved by decreasing of patients’ assessment of pain by visual analogue scale at the end of study by 44 % (p < 0.05) at rest, and by 62 % (p < 0.05) on movement compared to the control group. Reduction in Lequesne index was more significant — by 48 % (p < 0.05). Majority of patients reported positive effects of hydrolyzed collagen (FORTIGEL®): 10 % — a significant improvement, 53 % — a mode­rate improvement and 37 % — unchanged. At the group of observation, there was more pronounced decrease in diclofenac sodium dosage compare to the control group at the end of study — by 73 and 47 %, respectively. No significant side effects requiring discontinuation of hydrolyzed collagen (FORTIGEL®) were recorded during the treatment.
рroFLEX (hydrolyzed collagen (FORTIGEL®)) is an effective and safe pre­paration for the complex treatment of patients with knee osteoarthritis.


Keywords


knee osteoarthritis; hydrolyzed collagen (FORTIGEL®); efficacy; safety

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DOI: https://doi.org/10.22141/1608-1706.1.17.2016.74165

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