Obesity-Induced Osteoarthritis: the Multifactorial Association and Leading Role of Adipokines, Dyslipidemia and Mechanical Loading

I.Yu. Golovach

Abstract


The article discribes current data and recent studies on possible connection between obesity, osteoarthritis and аdipokines. Obesity is a well-known risk factor for development of osteoarthritis. The link between overweight and osteoarthritis cannot be explained by the increased joint load accompanying obesity. However, the association between obesity and osteoarthritis in non-weight-bearing joints suggests a more complex aetiology for obesity-induced weight-bearing. Today, adipose tissue is regarded as an endocrine organ that produces substances with local and systemic effects. The best-known and well researched аdipokines are leptin, adiponectin, resistin and visfatin, the role of which in the pathogenesis of osteoarthritis and other rheumatic diseases is discussed extensively. Adipokines may influence articular cartilage in different ways. On the one hand, they raise the level of proinflammatory factors; on the other hand they have anti-inflammatory potential. Subsequently, the effects of a lipid dysmetabolism, low-grade inflammation on joint tissues are discussed and linked to osteoarthritis. Thus, the association between obesity and osteoarthritis is beyond the mechanical loading and generates separate clinical-pathogenic phenotype of the disease.


Keywords


osteoarthritis; obesity; adipokines; dyslipidemia; pathogenesis

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DOI: https://doi.org/10.22141/1608-1706.4.16.2015.80172

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