The Role of Symptom-Modifying and Structure-Modifying Drugs in the Treatment of Osteoarthritis: a Place of phytosterols Unsaponifiables

I.Yu. Golovach

Abstract


The general approaches to the treatment of osteoarthritis and the main groups of drugs being used in the treatment of this disease are considered. The latest 2014 guidelines on the approaches to the treatment of osteoarthritis are presented. Features of symptom-modifying and structural-modifying drugs are discussed. Piascledine 300, containing avocado and soybeans unsaponifiables in the ratio 1 : 2, belongs to the drugs with chondroprotective and structure-modifying properties. Piascledine is described as anticytokine agent, its action is directed at correcting a number of processes which underlie the impaired metabolism of cartilage in osteoarthritis. The results of the studies on symptom-modifying and structure-modifying effects of this drug are presented.


Keywords


osteoarthritis; unsaponifiables compounds of phytosterols and of fatty acids; Piascledine 300; treatment; cytokines; structure-modifying effect; symptom-modifying effect; guidelines

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DOI: https://doi.org/10.22141/1608-1706.1.16.2015.80174

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