Stress-Induced Hyperalgesia in Patients with Combined and Multiple Trauma

I.L. Kuchyn


The aim of the study was to determine the effect of trauma and repeated surgical interventions on the development of hyperalgesia and intensity of postoperative pain in patients with multiple skeletal trauma. Materials and methods. 92 patients with multiple trauma were undergone an orthopedic surgery. Patients were divided into groups depending on the surgery number and replication. Pain assessment was carried out with visual analogue scale. To determine the mechanical pain threshold a set of 10-calibrated Von Frey monofilaments was used. To detect a difference between groups Mann — Whitney test and Fisher dual criterion were used. Results. Significantly more intensive pain was observed in the group of repeated surgeries. The difference in required emergency analgesia was also significant (p < 0.01). The pressure by Von Frey monofilaments, causing pain in the forearm in 1st day varied significantly between the studied groups, pain in the postoperative period was stronger in patients in acute trauma compared with patients underwent routine surgery on removing hardware. Conclusions. In patients with multiple or combined trauma after repeated surgery postoperative pain was of a higher intensity due to the development of stress-induced hyperalgesia. Adequate perioperative analgesia improves treatment outcomes in patients with associated and multiple trauma.


combined trauma; perioperative analgesia; postoperative pain; stress-induced hyperalgesia


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