Standard Indicators of Trabecular Bone Score and Bone Mineral Density at the Lumbar Spine in Ukrainian Women of Various Ages

V.V. Povorozniuk, N.I. Dzerovych, A.S. Musiienko

Abstract


The objective of the study was to assess the indicators of trabecular bone score (TBS) and bone mineral density (BMD) at the lumbar spine in Ukrainian apparently healthy women of various ages. On the basis of Ukrainian scientific and medical center of osteoporosis problems, there were examined 497 apparently healthy women aged 20 to 89 years, who were divided into seven groups by decades. The study didn’t include women with bone mineral density at the lumbar spine and femoral neck with value of Z-criterion out of range ± 2 SD, early menopause (45 years), obesity (body mass index > 30 kg/m2), diseases that affect bone metabolism. BMD at the lumbar spine (L1–L4) was assessed using dual-energy X-ray absorptiometry (Prodigy, GE Lunar, Madison, USA). Indicator of TBS (L1–L4) was determined by means of TBS iNsight technique (Med-Imaps, Pessac, France). As a result, the study found that the maximum value of TBS (L1–L4) and BMD at the lumbar spine (L1–L4) were detected in women aged 30–39 years. Significantly lower rate of TBS (L1–L4) compared with women aged 30–39 years has been found in the age groups 50–59, 60–69, 70–79 and 80–89 years, of BMD at the lumbar spine (L1–L4) — in the age groups 40–49, 50–59, 60–69, 70–79 and 80–89 years. Decline in TBS (L1–L4) increased significantly with age — from –3.11 % in the age group 40–49 years to –18.68 % in the age group 80–89 years. The lowest rates of BMD at the lumbar spine (L1–L4) were observed in surveyed women aged 40–49 years — –16.97 %. At that, in the age group 80–89 years BMD was –9.50 %. Revealed changes in BMD are due to the development of degenerative-dystrophic changes at the spine with age. Thus, the importance of factors that determine bone strength is different in various age periods. Our results confirm the independence of TBS indicator in determining the structural and functional state of bone tissue and risk of osteoporotic fractures. There was found a negative regression relationship between duration of postmenopausal period of a woman and TBS index. When carrying out regression analysis between indicators of trabecular bone score and bone mineral density at the lumbar spine (L1–L4) in the whole group, there was found a probable positive correlation (p = 0.0001). When studying regression relationship in different age groups, a probable dependence was found only in women from age group 30–39 years. Given our results, we believe that in evaluating the structural and functional state of bone and determining the risk of fracture in each age period, there must be an individual approach to the patient.


Keywords


trabecular bone score; bone mineral density; age; women

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DOI: https://doi.org/10.22141/1608-1706.2.16.2015.80252

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