Standard Indicators of Trabecular Bone Score and Bone Mineral Density at the Lumbar Spine in Ukrainian Women of Various Ages
The objective of the study was to assess the indicators of trabecular bone score (TBS) and bone mineral density (BMD) at the lumbar spine in Ukrainian apparently healthy women of various ages. On the basis of Ukrainian scientific and medical center of osteoporosis problems, there were examined 497 apparently healthy women aged 20 to 89 years, who were divided into seven groups by decades. The study didn’t include women with bone mineral density at the lumbar spine and femoral neck with value of Z-criterion out of range ± 2 SD, early menopause (45 years), obesity (body mass index > 30 kg/m2), diseases that affect bone metabolism. BMD at the lumbar spine (L1–L4) was assessed using dual-energy X-ray absorptiometry (Prodigy, GE Lunar, Madison, USA). Indicator of TBS (L1–L4) was determined by means of TBS iNsight technique (Med-Imaps, Pessac, France). As a result, the study found that the maximum value of TBS (L1–L4) and BMD at the lumbar spine (L1–L4) were detected in women aged 30–39 years. Significantly lower rate of TBS (L1–L4) compared with women aged 30–39 years has been found in the age groups 50–59, 60–69, 70–79 and 80–89 years, of BMD at the lumbar spine (L1–L4) — in the age groups 40–49, 50–59, 60–69, 70–79 and 80–89 years. Decline in TBS (L1–L4) increased significantly with age — from –3.11 % in the age group 40–49 years to –18.68 % in the age group 80–89 years. The lowest rates of BMD at the lumbar spine (L1–L4) were observed in surveyed women aged 40–49 years — –16.97 %. At that, in the age group 80–89 years BMD was –9.50 %. Revealed changes in BMD are due to the development of degenerative-dystrophic changes at the spine with age. Thus, the importance of factors that determine bone strength is different in various age periods. Our results confirm the independence of TBS indicator in determining the structural and functional state of bone tissue and risk of osteoporotic fractures. There was found a negative regression relationship between duration of postmenopausal period of a woman and TBS index. When carrying out regression analysis between indicators of trabecular bone score and bone mineral density at the lumbar spine (L1–L4) in the whole group, there was found a probable positive correlation (p = 0.0001). When studying regression relationship in different age groups, a probable dependence was found only in women from age group 30–39 years. Given our results, we believe that in evaluating the structural and functional state of bone and determining the risk of fracture in each age period, there must be an individual approach to the patient.
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Поворознюк В.В. Захворювання кістково-м’язової системи в людей різного віку (вибрані лекції, огляди, статті): У 3 томах. — К., 2009. — 664 c.
Поворознюк В.В., Дзерович Н.И. Качество трабекулярной костной ткани у женщин различного возраста // Боль. Суставы. Позвоночник. — 2011. — № 4. — С. 29-31.
Поворознюк В.В., Мусиенко А.С., Дзерович Н.И. Минеральная плотность и качество костной ткани, 10-летний риск остеопоротических переломов у украинских мужчин различного возраста // Боль. Суставы. Позвоночник. — 2013. — № 3. — С. 52-55.
Barbara C.S., John P.B. Trabecular bone score: perspectives of an imaging technology coming of age // Arq. Bras. Endocrinol. Metab. — 2014. — 58/5. — Р. 493-503.
Cormier C., Lamy O., Poriau S. TBS in routine clinical practice: proposals of use // Atlas of TBS use. — 2012. — 16.
Dufour R., Winzenrieth R., Heraud A., Hans D., Mehsen N. Generation and validation of a normative, age-specific reference curve for lumbar spine trabecular bone score (TBS) in French women // Osteoporos. Int. — 2013. — № 24(11). — Р. 2837-46.
El Hage R., Khairallah W., Bachour F., Issa M., Eid R., Fayad F. et al. Influence of Age, Morphological Characteristics, and Lumbar Spine Bone Mineral Density on Lumbar Spine Trabecular Bone Score in Lebanese Women // Clin. Densitom. — 2013. — № 17(3). — Р. 434-435.
Hans D., Winzenrieth R. Estimation of Bone microarchitecture Pattern from AP spine DXA scans using the Trabecular Bone Score (TBS): An added value in clinical routine for the patient. A short review // Osteologický bulletin. — 2011. — 16(3). — P. 70-78.
Povoroznyuk V.V., Del Rio L., Di Gregorio S. et al. Is TBS different in healthy european caucasian men and women? Creation of normative spine tbs data for men // Program and abstract book (ASBMR 2014 Annual Meeting, 12–15 September 2014, Texas, USA). — 2014. — Poster MO0290.
Povoroznyuk V.V., Del Rio L., Di Gregorio S. et al. Is TBS different in healthy european caucasian men and women? Creation of normative spine tbs data for men // Боль. Суставы. Позвоночник. — 2014. — № 3. — С. 20-23.
Rabier B., Héraud A., Grand-Lenoir C. et al. A multicentre, retrospective case-control study assessing the role of trabecular bone score (TBS) in menopausal Caucasian women with low areal bone mineral density (BMDa): Analysing the odds of vertebral fracture // Bone. — 2010. — 46. — P. 176-181.
Silva B.C., Leslie W.D., Resch H. et al. Trabecular bone score: a noninvasive analytical method based upon the DXA image // Journal of Bone and Mineral Research. — 2014. — 29(3). — P. 518-530.
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