Comparative Results of Comprehensive Treatment for Metastatic Bone Disease in Kidney Cancer Using Sorafenib

V.V. Protsenko, A.V. Ilnitskyi

Abstract


The article deals with the combined treatment of 56 patients with metastatic bone disease in renal cell carcinoma. The main group included 29 patients, in whom we have applied surgical treatment, radiation therapy, bisphosphonates (pamiredin, zoledronic acid) and targeted therapy (sorafenib) in the schemes of comprehensive treatment. As a result of the treatment, there has been achieved an improvement in the functional activity of the operated limb (excellent and good results — by 67.7 %), reduction of pain syndrome and survival rate of patients over 3 years (41.8 %) compared with 27 patients in the control group, who received radiotherapy, bisphosphonates, chemotherapy (5-fluorouracil), hormone therapy and immunotherapy.

Keywords


kidney cancer; bone metastases; complex treatment; surgical treatment; sorafenib

References


Бур’янов О.А. Наш досвід лікування хворих з метастатичним ураженням кісток / О.А. Бур’янов, В.В. Проценко, В.С. Чорний // Травма. — 2011. — Т. 12, № 2. — С. 112-114.

Тепляков В.В. Хирургическое лечение патологических переломов длинных трубчатых костей при метастатическом поражении / В.В. Тепляков, В.Ю. Карпенко, А.К. Валиева // Вопросы онкологии. — 2005. — Т. 51, № 3. — С. 377-381.

Хирургическое лечение больных с метастатическими поражениями длинных костей / Р.М. Тихилов, П.В. Григорьев, Ф.Ю. Засульский [и др.]: Мат-лы Всероссийской конф. с международным участием «Эндопротезирование крупных суставов» (Москва, 21–22 апреля). — М., 2009. — С. 120.

Bauer H.C. Controversies in the surgical management of skeletal metastases / H.C. Bauer // J. Bone Joint Surg. Br. — 2005. — Vol. 87. — P. 608-617.

Bauer H.C. Survival after surgery for spinal and extremity metastases. Prognostication in 241 patients / H.C. Bauer, R. Wedin // Acta Prthop. Scand. — 1995. — Vol. 66, № 2. — P. 143-146.

Bickels J. Surgical management of metastatic bone di­sease / J. Bickels, S. Dadia, Z. Lilar // J. Bone Joint. Sarg. Am. — 2009. — Vol. 91, № 6. — P. 1503-1516.

Cancer statistics, 2004. / А. Jemal, R.C. Tiwari, T. Murray [et al.] // CA Cancer J. Clin. — 2004. — № 54(1). — Р. 8-29.

Cappana R. A new protocol of surgical treatment of long bone metastases / R. Cappana, P. De Biase, D. A. Campanacci // Ortop. Traumatol. Rehabil. — 2003. — Vol. 5, № 3. — P. 271-275.

Damron T.A. Surgical treatment for metastatic disease of the pelvis and the proximal end of the femur / T.A. Damron, F.H. Sim // Instructional Course Lectures. — 2000. — Vol. 49. — P. 461-470.

Godley P.A. Renal cell carcinoma / P.A. Godley, M. Taylor // Curr. Opin. Oncol. — 2001. — № 13. — Р. 199-203.

Interferon-alpha as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma / R.J. Motzer, J. Bacik, B.A. Murphy [et al.] // J. Clin. Oncol. — 2002. — № 20. — Р. 289-296.

Randomized phase III trial of sorafenib in advanced renal cell carcinoma (RCC): impact of crossover on survival / T. Elsen, R.M. Bukowski, M. Staehler [et al.] // J. Clin. Oncol. — 2006. — Vol. 24. — P. 22 (abstr 4524).

Randomized phase II trial of the multi-kinase inhibitor sorafenib versus interferon (IFN) in treatment naive patients with metastatic renal cell carcinoma (mRCC) / B. Escudier, C. Szczylik, T. Demkow [et al.] // J. Clin. Oncol. — 2006. — Vol. 24. — P. 18 (abstr. 4501).

Sim F.H. Metastatic bone disease of the pelvic and femur / F.H. Sim // Instr. Course Lect. — 1992. — Vol. 41. — P. 317-327.

Sorafenib in advanced clear-cell carcinoma / B. Escudier, T. Eisen, W.M. Stadlier [et al.] // N. Engl. J. Med. — 2007. — Vol. 356. — Р. 125-134.

Successful limb salvage of pathological fracture of the distal tibia caused by cancer metastasis / H. Futani, S. Kamae, K. Atsui [et al.] // Orthop. Sci. — 2002. — Vol. 7, № 2. — P. 262-266.

Surveilance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. / N.K. Janzen, H.L. Kim, R.A. Figlin [et al.] // Urol. Clin. North Am. — 2003. — № 30(4). — Р. 843-852.




DOI: https://doi.org/10.22141/1608-1706.2.16.2015.80263

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 TRAUMA

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru