The Influence of Calcitonin on Fracture Healing

V.V. Povoroznyuk, N.V. Dedukh, A.V. Makogonchuk


The study was conducted on 60 adult females rats Vistar aged 6 months. All animals were undergone a perforated defect of femur distal metaepiphysis under ether inhalation anesthesia. The animals were divided into 3 groups of 20 animals in each one: group A consisted of the animals being calcitonin administered from the 2nd day after surgery; group B involved the animals being calcitonin administered after the 5th day after the operation; group C was a control one, without the administration of the drug. The animals of groups A and B received calcitonin subcutaneously at a dose of 10 mg/kg per day. The animals were sacrificed on the 3rd and 7th, 14th and 28th day (5 animals in each group) by ether overdosing. The taken material was histologically analyzed.
The study found that calcitonin application in animals with traumatic metaphyseal femur on the reparative osteogenesis stage embracing inflammation (group A) was ineffective. There is a slowing down of the restructuring of the mature bone fragments and reduced reparative potential. More optimistic forecast can be made in the animals injected on the stage of proliferation (group B), cell differentiation and the beginning of tissue structures formation. On the 28th day formed lamellar bone tissue with the higher density of cellular components in traumatic area was observed in comparison with group A and the control one.


fracture healing; calcitonin


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