The Influence of Calcitonin on Fracture Healing
The study was conducted on 60 adult females rats Vistar aged 6 months. All animals were undergone a perforated defect of femur distal metaepiphysis under ether inhalation anesthesia. The animals were divided into 3 groups of 20 animals in each one: group A consisted of the animals being calcitonin administered from the 2nd day after surgery; group B involved the animals being calcitonin administered after the 5th day after the operation; group C was a control one, without the administration of the drug. The animals of groups A and B received calcitonin subcutaneously at a dose of 10 mg/kg per day. The animals were sacrificed on the 3rd and 7th, 14th and 28th day (5 animals in each group) by ether overdosing. The taken material was histologically analyzed.
The study found that calcitonin application in animals with traumatic metaphyseal femur on the reparative osteogenesis stage embracing inflammation (group A) was ineffective. There is a slowing down of the restructuring of the mature bone fragments and reduced reparative potential. More optimistic forecast can be made in the animals injected on the stage of proliferation (group B), cell differentiation and the beginning of tissue structures formation. On the 28th day formed lamellar bone tissue with the higher density of cellular components in traumatic area was observed in comparison with group A and the control one.
Full Text:PDF (Русский)
Поворознюк В.В., Григорьева Н.В. Медицинский светофор // Боль. Суставы. Позвоночник. — 2012. — 3(07).
Aspenberg P. Drugs and fracture repair // Acta Orthop. — 2005. — 76. — 241-248.
Augat P., Simon U., Liedert A., Claes L. Mechanics and mechano-biology of fracture heaing in normal and osteoporotic bone // Osteoporos. Int. — 2005. — 16. — S36-S43.
Barrios C., Brostrom L.A., Stark A., Walheim G. Healing complications after internal fixation of trochanteric hip fractures: the prognostic values of osteoporosis // J. Orthop. Trauma. — 1993. — 7. — 438-442.
Cebosoy O., Tutar E., Kose K.C., Baltaci Y., Bagci C. Effect of strontium ranelate on fracture healing in rat tibia // Joint Bone Spine. — 2007. — 74. — 590-593.
Cipriano C.A., Issack P.S., Shindle L., Werner C.M., Helfet D.L., Lane J.M. Recent advances toward the clinical application of PTH (1-34) in fracture healing // HSS J. — 2009. — 5. — 149-153.
Cummings S.R., Melton L. Jr. Epidemiology and outcomes of osteoporotic fractures // Lancet. — 2000. — 359. — 1761-1767.
Ekeland A., Muhre L., Underdal T. Effects of salmon calcitonin on mechanical properties of healing and intact bone and skin in rats // Acta Orthop. Scand. — 1983. — 54. — 760-767.
Fleisch H. Can bisphosphonates be given to patients with fractures? // J. Bone Miner. Res. — 2001. — 16. — 437-440.
Frost H.M. The biology of fracture healing. An overview for clinicians. Part I // Clin. Orthop. — 1989. — 248. — 150-162.
Goldhahn J., Scheele W.H., Mitlak B.H. et al. Clinical evaluation of medicinal products for acceleration of fracture healing in patients with osteoporosis // Bone. — 2008. — 43. — 343-347.
Johnson-Lynn S.E., Francis R., McCaskie A. Osteoporosis treatments and their effect on fracture healing // Curr. Orthop. — 2008. — 2. — 336-340.
Kolar J., Babicky A., Blahos J. Influence of 25-hydroxy-calciferol and calcitonin on experimental fractures // Acta Chir. Orthop. Traumatol. — 1979. — 46. — 193-199.
Lewiecki E.M. Emerging drugs for postmenopausal osteoporosis // Expert. Opin. Emerg. Drugs. — 2009. — 14. — 129-144.
Lyritis G.P., Boscainos P.J. Calcitonin effects on cartilage and fracture healing // J. Musculoskel. Neuron. Interact. — 2001. — 2. — 137-142.
Lyritis G.P. Fracture healing and antiosteoporotic treatments // Medicographia. — 2010. — 32. — 79-85.
McKibbin B. The biology of fracture healing in long bones // J. Bone Joint Surg. Br. — 1978. — 60B. — 150-162.
Meyer R.A. Jr, Tsahakis P.J., Martin D.F., Banks D.M., Harrow M.E., Kiebzak G.M. Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats // J. Orthop. Res. — 2001. — 19. — 428-435.
Nozaka K., Miyakoshi N., Kasukawa Y., Maekawa S., Noguchi H., Shimada Y. Intermittent administration of human parathyroid hormone enhances bone formation and union at the site of cancellous bone osteotomy in normal and ovariectomized rats // Bone. — 2008. — 42. — 90-97.
Paavolainen P., Taivainen T., Michelsson J.-E., Lalla M., Penttinen R. Calcitonin and fracture healing. An experimental study on rats // J. Orthop. Res. — 1989. — 100-106.
Rizzoli R. A new treatment for post-menopausal osteoporosis: strontium ranelate // J. Endocrinol. Invest. — 2005. — 28(suppl. 8). — 50-57.
Schatzker J., Chapman M., Ha’Eri G.B., Fornasier V.L. The effect of calcitonin on fracture healing // Clin. Orthop. — 1979. — 141. — 303-306.
- There are currently no refbacks.
Copyright (c) 2016 TRAUMA
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2018