Impact of Systemic Osteoporosis on Reparative Regeneration of Bone Tissue

V.V. Povoroznyuk, A.V. Makogonchuk

Abstract


An experimental study was carried out on 40 sexually mature Vistar females rats aged 6 months. Animals were divided into two groups of 20 subjects each. Rats of 1st group underwent bilateral spaying. Rats from 2nd group hadn’t been spayed. After spaying the animals were observed for 4 months, required for the development of a model of postmenopausal osteoporosis in animals of main (1st) group. Then distal perforating metaepiphyseal fracture of the femur was done to both groups of animals. The following methods of investigation had been used: dual-energy X-ray densitometry, histomorphologic study, biomechanical studies of the regenerate. It is found that the presence of systemic osteoporosis in experimental animals has no effect on the clinical course of reparative process in the early and middle stages of callus formation, but likely causes reduction of qualitative and quantitative indicators of the regenerate in stages of formation and mineralization of osteoid compared with animals of the control group.


Keywords


regeneration of bone tissue; spaying; osteoporosis

References


Лузин В.И., Астраханцев Д.А. Методика определения микротвердости минерализованных тканей зубочелюстного сегмента нижней челюсти в эксперименте // Український морфологічний альманах. — 2005. — Т. 3, № 3. — С. 42-44.

Giannoudis P., Tzioupis C., Almalki T., Buckley R. Fracture healing in osteoporotic fractures:Is it really different? A basic science perspective // Injury, Int. J. Care Injured. — 2007. — 38S1. — P. 90-99.

Dreinhofer K.E. Multinational survey of osteoporotic fracture management // Osteoporos Int. — 2005 — 16, Suppl. 2. — P. 44-53.

Egermann M.J., Schneider G.E. Animal models for fracture treatment in osteoporosis // Osteoporos Int. — 2005 — 16. — P. 129-138.

Ekeland A., Engesoeter L.B., Langeland N. Influence of age on mechanical properties of healing fractures and intact bones in rats // Acta Orthop. Scand. — 1982. — 53. — P. 527-534.

Garland D. Clinical observations on fractures and heterotopic ossification in the spinal cord and traumatic brain injured populations // Clin. Orthop. — 1988. — 233. — P. 86-101.

Gullberg B., Johnell O., Kanis J.A. Worldwide projections for hip fracture // Osteoporos Int. — 1997. — P. 407-413.

Lill C.A., Fluegel A.K., Schneider E. Sheep model for fracture treatment in osteoporotic bone: a pilot study about different induction regimens // J. Orthop. Trauma. — 2000. — 14. — P. 559-566.

Melhus G., Solberg L.B., Dimmen S., Madsen J.E. et al. Experimental osteoporosis induced by ovariectomy andvitamin D deficiency does not markedly affect fracture healing in rats // Acta Orthopaedica. — 2007. — 78. — 3. — P. 393-403.

Meyer R.A. Jr., Tsahakis P.J., Martin D.F. Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats // J. Orthop. Res. — 2001. — 19. — P. 428-35.

Pape H.C., Hildebrand F., Krettek C., Green J., Giannoudis P.V. Experimental background — review of animal studies // Injury, Int. J. Care Injured. — 2006. — 37S. — P. 25-38.

Qiao L., Xu K.H., Liu H.W., Liu H.Q. Effects of ovariectomy on fracture healing in female rats // Sichuan Da Xue Xue Bao Yi Xue Ban. — 2005. — 36. — P. 108-111.

Richard D.,Wasnich M.D. Epidemiology of osteoporosis // Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. NewYork: Lippincott-Raven, 1996. — P. 249-251.

Silver J.J., Einhorn T.A. Osteoporosis and aging: Current update // Clin. Orthop. — 1995. — 316. — P. 10-20.

Sterck J.G., Klein-Nulend J., Lips P., Burger E.H. Response of normal and osteoporotic human bone cells to mechanical stress in vitro // Am. J. Physiol. — 1998. — 274. — P. 1113-1120.

Syed A.A., Agarwal M., Giannoudis P.V. et al. Distal femoral fractures: longterm outcome following stabilisation with the LISS // Injury. — 2004. — 35. — P. 599-607.

U.S. Department of Health and Human Services. Bone Health and Osteoporosis. A report of the US Surgeon General, Rockville MD. — 2004.

Wang J.W., Li W., Xu S.W. et al. Osteoporosis influences the middle and late periods of fracture healing in a rat osteoporotic model // Chin. J. Traumatol. — 2005. — 8. — P. 111-116.




DOI: https://doi.org/10.22141/1608-1706.2.14.2013.88590

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 TRAUMA

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru