Impact of Systemic Osteoporosis on Reparative Regeneration of Bone Tissue

V.V. Povoroznyuk, A.V. Makogonchuk


An experimental study was carried out on 40 sexually mature Vistar females rats aged 6 months. Animals were divided into two groups of 20 subjects each. Rats of 1st group underwent bilateral spaying. Rats from 2nd group hadn’t been spayed. After spaying the animals were observed for 4 months, required for the development of a model of postmenopausal osteoporosis in animals of main (1st) group. Then distal perforating metaepiphyseal fracture of the femur was done to both groups of animals. The following methods of investigation had been used: dual-energy X-ray densitometry, histomorphologic study, biomechanical studies of the regenerate. It is found that the presence of systemic osteoporosis in experimental animals has no effect on the clinical course of reparative process in the early and middle stages of callus formation, but likely causes reduction of qualitative and quantitative indicators of the regenerate in stages of formation and mineralization of osteoid compared with animals of the control group.


regeneration of bone tissue; spaying; osteoporosis


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