Diagnosis of osteomalacia and osteoporosis in postmenopausal women

Authors

  • O.M. Ignatiev Odessa National Medical University, Odesa, Ukraine
  • M.I. Turchin Odessa National Medical University, Odesa, Ukraine
  • T.O. Ermolenko Odessa National Medical University, Odesa, Ukraine
  • O.D. Kichmarenko Odessa I.I. Mechnikov National University, Odesa, Ukraine

DOI:

https://doi.org/10.22141/1608-1706.1.23.2022.879

Keywords:

postmenopause, osteomalacia, osteoporosis, diagnosis

Abstract

Despite a similar clinical outcome (fractures), morphostructural, etiological and pathogenetic characteristics, osteoporosis and osteomalacia differ qualitatively, and treatment regimens for these conditions will be different. To rule out a diagnostic error before prescribing treatment, the patient must undergo differential diagnostic measures to determine the cause of decreased bone mine-
ral density. We observed 65 postmenopausal women aged on ave-rage 62.30 ± 2.74 years, with reduced bone mineral density, who underwent morphological examination of bone tissue during hip arthroplasty for femoral neck fracture. X-ray densitometry was performed on Hologic Discovery bone densitometer (USA). Functional assessment of the musculoskeletal system was performed using the InsightTM device. The level of vitamin D (25(OH)D) in the blood serum was evaluated, as well as osteoprotegerin, C-terminal telopeptide of type 1 collagen, bone turnover marker. A mathematical model has been created that allows predicting the value of the morphological indicator “high functional activity of bone tissue cells” in osteomalacia and osteoporosis through other, the simplest and accessible laboratory parameters (25(OH)D, C-terminal telopeptide of type 1 collagen, osteoprotegerin), according to X-ray densitometry and examination on the InsightTM device (algometry and inclinometry).

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References

Anumula S., Magland J., Wehrlib S.L., Ong H., Song H.K., Wehrli F.W. Multi-modality study of the compositional and mechanical implications of hypominerali-zation in a rabbit model of osteomalacia. Bone. 2008. (2). 405-413.

Ascenzi M.-G., Hetzer N., Lomovtsev A., Rude R., Nattiv A., Favia A. Variation of trabecular architecture in proximal femur of postmenopausal women. J. Biomechanics. 2011. 44(2). 248-256.

Arya V., Jain V. Osteomalacia – what the rheumatologist needs to know. Indian J. Rheumatology. 2007. 2(1). 17-22.

Аврунин А.С. Оcтеопороз и остеомаляция — клинико-диагностические проблемы. Травматология России. 2014. № 4. С. 67-76.

Boivin G., Bala Y., Doublier A., Farlay D., Ste-Marie L.G., Meunier P.J., Delmas P.D. The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients. Bone. 2008. (3). 532-538.

Demay M.B., Krane S.M. Disorders of calcification: osteomalacia and rickets. Endocrinology: adult and pediatric. Saunders. 2010. 70. 1311-1329.

Bhan A., Rao A.D., Rao D.S. Osteomalacia as a Result of Vitamin D Deficiency. Endocrinol. Metab. Clin. N. Am. 2010. 39. 321-331.

Russell L.A. Osteoporosis and Osteomalacia. Rheum. Dis. Clin. North Am. 2010. 36(4). 665-680.

Lewiecki E.M., Bilezikian J.P., Cooper C., Hochberg M.C., Luckey M.M., Maricic M., Miller P.D. Proceedings of the Eighth Annual Santa Fe Bone Symposium. August 3–4, 2007. J. Clinical Densitometry: Assessment of Skeletal Health. 2008. (2). 313-324.

Kanis J.A., McCloskey E.V., Johansson H., Oden A., Melton III L.J., Khaltaev N. A reference standard for the description of osteoporosis. Bone. 2008. (3). 467-475.

Siminoski K., Leslie W.D., Frame H., Hodsman A., Josse R.G., Khan A., Lentle B.C., Lévesque J., Lyons D.J., Tarulli G., Brown J.P. Recommendations for Bone Mineral Density Reporting in Canada. JACR. 2005. 56(3). 178-188.

Пикалюк В.С., Кутя С.А., Шадуро Д.В. Модификация методики гистологического исследования костной ткани. Морфологія. 2010. № 3. С. 72-76. Режим доступу до журналу: http://www.morphology.dp.ua/_pub/MORPHO-2010-04-03/10pvsikt.pdf

Published

2022-05-16

How to Cite

Ignatiev, O., Turchin, M., Ermolenko, T., & Kichmarenko, O. (2022). Diagnosis of osteomalacia and osteoporosis in postmenopausal women. TRAUMA, 23(1), 30–35. https://doi.org/10.22141/1608-1706.1.23.2022.879

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Original Researches

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